In Re Topamax Litigation, 110602131, Court of Common Pleas, Philadelphia County, Pennsylvania.
An April 1 court order disclosed that Johnson & Johnson and its subsidiary Janssen Pharmaceuticals have agreed to settle 76 Topamax cases brought in a Pennsylvania state court. Topamax is approved by the FDA for the treatment of epilepsy and the prevention of migraines in adults and adolescents. The lawsuits allege that Topamax caused birth defects including cleft palettes and other malformations in children born to women taking the epilepsy drug. Details of the settlements were not disclosed by the court. The settlements follow three multi-million dollar awards against J&J of $4 million in October 2013, $11 million in November 2013, and $3 million in March 2014. Although the settled cases were removed from the docket, about 60 Topamax cases remain with the state court. Read more about Topamax lawsuits.
 In Re Topamax Litigation, 110602131, Court of Common Pleas, Philadelphia County, Pennsylvania.
A jury in Philadelphia has returned a $3 million against Johnson & Johnson, maker of the anti-epilepsy drug Topamax. The family that filed suit claimed their child was born with a cleft lip after her mother took Topamax to treat migraines during her pregnancy. The jury found that the company failed to warn the woman of the risk of birth defects when taken during pregnancy. Studies have shown that Topamax increases the incidents of cleft lips and cleft palates in newborns when taken by mothers during pregnancy. More than 130 additional Topamax cases are pending as a part of the Philadelphia court system's mass tort program.
 Orzeck, K. "J&J Unit Hit With $3M Jury Verdict in Topamax Row," Law360 (March 7, 2014).
A new class action alleges Forest Pharmaceuticals covered up the potential risks of the antidepressants Lexapro and Celexa. Plaintiffs argue that the manufacturer concealed findings that the drugs were not effective in children. Lexapro has also been the subject of litigation alleging that the drug causes birth defects such as heart defects, craniosynostosis, oral clefts, and club foot.